tissue plasminogen activator (TPA)

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• Tissue plasminogen activator — (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC number|3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the… …   Wikipedia

• tissue plasminogen activator — n a clot dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart… …   Medical dictionary

• tissue plasminogen activator — noun a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction • Syn: ↑Activase • Usage Domain: ↑trade name (for: ↑Activase) • Hypernyms: ↑ …   Useful english dictionary

• tissue plasminogen activator — An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator …   English dictionary of cancer terms

• recombinant tissue plasminogen activator — A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of… …   English dictionary of cancer terms

• tissue plasminogen activator — (= TPA; tPA) Plasma serine protease, one of a closely related group of plasminogen activators. Contains an EGF like domain and multiple copies of the kringle domain …   Dictionary of molecular biology

• Активатор Плазминогена Тканевый (Tissue Plasminogen Activator, Tpa, Tpa) — присутствующий в организме белок, способный разрушать образующиеся тромбы (см. Тромболиз); в настоящее время его получают методами генетической инженерии (см. Альтеплаза). Этот белок требует обязательного присутствия в организме фибрина, который… …   Медицинские термины

• Plasminogen activator inhibitor-1 — Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 PAI 1 in complex with the SMB domain of Vitronectin PDB 1OC0 …   Wikipedia

• tissue plasminogen activator — noun Date: 1981 a clot dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce… …   New Collegiate Dictionary

• Tissue plasminogen activator — Activateur tissulaire du plasminogène Fibrinolyse. L activateur tissulaire du plasminogène (t PA) est une enzyme protéolytique initiant la fibrinolyse. Elle est sécrété par l endothélium vasculaire plusieurs jours après lésion de celui ci et son… …   Wikipédia en Français

• tissue plasminogen activator — Biochem. 1. an anticlotting enzyme, naturally occurring in small amounts in the blood. 2. Pharm. the same enzyme, produced in large amounts by genetic engineering techniques for use in dissolving blood clots. Abbr.: TPA * * * …   Universalium